Figure 3.

Poly(lactic acid) particles were implanted in neutrophil-depleted versus control mice for 24 hours prior to formyl peptide receptor-targeting nanoprobe administration. (A) Representative image of hematoxylin and eosin staining (200×) of the implant sites and quantification analysis of inflammatory cells. (B) Representative image of immunohistochemical staining (600×) and quantification analysis of neutrophils. (C) Fluorescence intensities at different time points (left panel) and in vivo image at 4 hours postinjection (right panel) illustrate the diminishing accumulation of formyl peptide receptor-targeting probes in neutrophildepleted animals in comparison with controls.

Abbreviations: H&E, hematoxylin and eosin; IHC, immunohistochemical; PLA, poly(lactic acid).