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. 2012 May 4;7:2293–2306. doi: 10.2147/IJN.S29152

Figure 3.

Figure 3

Therapeutic efficiency of GT–SPE as an aerosol gene delivery carrier in lung cancer model K-rasLA1 mice. Aerosol delivery of GT–SPE/Akt1 shRNA significantly inhibited lung tumor numbers and tumorigenesis. (A) Lung tumor lesions. (B) Total tumor numbers (n = 4, **P <0.01 compared to shAkt1 only, GT–SPE/Scr, and control). (C) Tumor size over 1 mm; tumor numbers (n = 4, *P <0.05 compared to control; **P < 0.01 compared to shAkt1 only; ***P < 0.001 compared to GT–SPE/Scr). (D) Histopathological features (Magnification, 200×).

Abbreviations: GT–SPE, glycerol triacrylate–spermine; MMP-9, matrix metalloprotease-9; PCNA, proliferating cell nuclear antigen; shAkt1, small hairpin Akt1.