Figure 4.

In vivo anticancer efficacy of PNP–sirolimus. (A) A549 tumor-bearing mice were treated with 20 mg/kg of PNP–sirolimus three times per week for 4 weeks by iv injection. Tumor volume was measured using a caliper (n = 6; *P < 0.005). (B) Body weight was monitored twice per week. (C) A549 tumor-bearing mice were treated with 20 mg/kg of PNP–sirolimus once per week for 4 weeks by iv injection (n = 6; *P < 0.005). (D) Body weight was monitored twice per week.

Abbreviations: PNP, polymeric nanoparticle; iv, intravenous.