Figure 6.

In vivo radiosensitization by PNP–sirolimus. Athymic nude mice with A549 xenograft tumors were treated with PNP or PNP–sirolimus (5 mg/kg), followed 2 hours later by radiation (2 Gy) for 5 consecutive days. (A) Average tumor volumes of six mice per group are shown. Error bars represent SD. Statistical analysis was performed using the Mann–Whitney test. P values < 0.005 were considered statistically very significant. *P = 0.0022. (B) Body weight of PNP–sirolimus and/or ionizing radiation-treated mice are shown.

Abbreviations: IR, ionizing radiation; PNP, polymeric nanoparticle; SD, standard deviation.