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Pharmacokinetic parameters in Sprague–Dawley rats following intravenous injection of sirolimus or PNP–sirolimus
| PK parameter | Free sirolimus (iv) | PNP–sirolimus (iv) |
|---|---|---|
| AUClast (μg · hours/mL) | 5366.7 | 16,901.7 |
| Cmax (μg/mL) | 2890 | 11,303.3 |
| Tmax (hours) | 0.25 | 0.25 |
| F (%) | 100 | 315 |
Abbreviations: AUC, area under the curve; Cmax, peak plasma concentration; F, absolute bioavailability; iv, intravenous; PNP, polymeric nanoparticle; Tmax, time to peak plasma concentration.
