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(A) Radiolabeling scheme of gold nanoshells with 64Cu through bifunctional OPSS-PEG-NHS and DOTA-NH2. (B) Ultraviolet-visible spectra of gold nanoshells before and after conjugation with OPSS-PEG-DOTA.
Abbreviations: PEG, polyethylene glycol; DOTA, 1,4,7,10-tetraazaciclododecane-1,4,7,10-tetraacetic acid; NS, gold nanoshells; NHS, hydroxysuccinimide ester; OPSS, opyridyldisulfide.
