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. 2012 Feb 21;7:9. doi: 10.1186/1745-6150-7-9

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Copyright ©2012 Graham et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Healthy and Penumbra cells without EPO. This figure shows the evolution of the healthy and penumbra (comprised of both catabolic and EPOR active) cell population densities over a period of 10 days. The results shown here correspond to a situation in which there is no production of or response to EPO. We see here that the healthy cell population is decimated. In accord with figure 4 and the corresponding mathematical model (equations (3-11)) this is due to the uninhibited influence of pro-inflammatory cytokines.