Table 2. Multivariate odds ratio of breast cancer risk associated with previous fever frequency and IFN-γ genotypes.
| Variables | Cases, n (%) | Controls, n (%) | OR (95%CI)a | OR (95%CI)b |
| Fever frequency (/year) | ||||
| <1 time | 556 (76.1) | 560 (72.1) | 1.00 (reference) | 1.00 (reference) |
| 1∼2 times | 141 (19.3) | 179 (23.0) | 0.79 (0.62–1.02) | 0.77 (0.59–1.00) |
| ≥3 times | 34 (4.7) | 38 (4.9) | 0.90 (0.56–1.45) | 0.79 (0.47–1.32) |
| P for trend | 0.136 | 0.056 | ||
| ≥1 time | 175 (23.9) | 217 (27.9) | 0.81 (0.64–1.02) | 0.77 (0.61–0.99) |
| IFN-γ rs2069705 | ||||
| CC | 407 (50.4) | 442 (52.6) | 1.00 (reference) | 1.00 (reference) |
| CT | 332 (41.1) | 342 (40.7) | 1.05 (0.86–1.29) | 1.06 (0.86–1.31) |
| TT | 68 (8.4) | 56 (6.7) | 1.32 (0.90–1.93) | 1.28 (0.87–1.90) |
| P for trend | 0.204 | 0.245 | ||
| CT+TT | 400 (49.6) | 398 (47.4) | 1.09 (0.90–1.32) | 1.09 (0.89–1.34) |
a
Adjusted for age.
b
Adjusted for age, BMI, age at menarche, marital status, education, parity, menopausal status, and family history of breast cancer.
Values in bold indicate statistical significance.