Table 4. Multivariate odds ratio of breast cancer associated with previous fever frequency by genotype of IFN-γ rs2069705.
| Variables | Variables | Cases, n (%) | Controls, n (%) | OR (95%CI)a | OR (95%CI)b |
| Genotype IFN-γ rs2069705 | Fever frequency (/year) | ||||
| CC | <1 time | 255 (72.9) | 297 (73.7) | 1.00 (reference) | 1.00 (reference) |
| ≥1 times | 95 (27.1) | 106 (26.3) | 1.05 (0.76–1.45) | 1.09 (0.77–1.55) | |
| CT/TT | <1 time | 279 (79.5) | 248 (69.9) | 1.00 (reference) | 1.00 (reference) |
| ≥1 times | 72 (20.5) | 107 (30.1) | 0.60 (0.42–0.84) | 0.54 (0.37–0.77) | |
| Fever frequency (/year) | Genotype IFN-γ rs2069705 | ||||
| <1 time | CC | 255 (46.2) | 297 (53.8) | 1.00 (reference) | 1.00 (reference) |
| CT/TT | 279 (52.9) | 248 (47.1) | 1.31 (1.03–1.67) | 1.32 (1.03–1.70) | |
| ≥1 times | CC | 95 (47.3) | 106 (52.7) | 1.00 (reference) | 1.00 (reference) |
| CT/TT | 72 (40.2) | 107 (59.8) | 0.75 (0.50–1.12) | 0.63 (0.40–0.99) | |
| P b for interaction (multiplicative/additive) | 0.020/0.055 | 0.005/0.058 | |||
a
Adjusted for age.
b
Adjusted for age, BMI, age at menarche, marital status, education, parity, menopausal status, and family history of breast cancer.
Values in bold indicate statistical significance.