Table 1. Neutralization sensitivity of the isogenic V3 recombinant HIV-1 to anti-gp120 monoclonal antibodies.
| Antibody ID | Ig subtype | Epitopes on Gp120 | ND50 (µg/ml)@ | |
| HIV-1LAI-NH1V3 | HIV-1LAI-TH09V3 | |||
| 49G2 | human IgG1 | CD4 binding site# | 0.224 | >10 |
| 42F9 | human IgG1 | CD4 binding site# | 0.934 | >10 |
| 0.5δ [59] | human IgG1 | CD4 binding site# | 0.444 | >10 |
| 4C11 [59] | human IgG2 | CD4 induced structure$ | >20 | >10 |
| 4301 | mouse IgG | broadly reactive* | 0.59 | 0.57 |
| 8D11 | human IgG1 | none | >20 | >10 |
#
Neutralization epitope in the Gp120 outer domain before CD4 binding.
$
Neutralization epitope induced in Gp120 after CD4 binding.
*
Epitopes outside of the CD4 binding site [37].
@
The effect of each antibody on viral infectivity was tested in duplicate.