Figure 9. B cell receptor signaling pathway representing the present and absent proteins in the pyrosequencing results.

Proteins appearing in the turbot transcriptome are represented in reddish color and absent proteins in grey color. PIR-B: paired-immunoglobulin like receptor-B; CD22: cluster of differentiation antigen 22; CD72: cluster of differentiation antigen 72; BCR: B cell receptor; FcgRIIB: Fc fragment of IgG, low affinity IIb, receptor; LEU13: leukocyte surface antigen LEU-13; CD81: cluster of differentiation antigen 81; CD19: cluster of differentiation antigen 19; CD21: cluster of differentiation antigen 21; SHP1: protein-tyrosine phosphatase-1; LYN: tyrosine-protein kinase Lyn; BCAP: B-cell phosphoinositide 3-kinase adapter protein; SHIP: SH-2-containing Inositol 5' Phosphatase; PI3K: phosphatidylinositol-4,5-bisphosphate 3-kinase; VAV: vav guanine nucleotide exchange factor; SYK: spleen tyrosine kinase; BTK: Bruton agammaglobulinemia tyrosine kinase; BLNK: B-cell linker; GRB2: growth factor receptor-binding protein 2; SOS: son of sevenless; PCL-γ2: phospholipase C gamma 2; PKCβ: protein kinase C beta; AKT: Rac serine/threonine-protein kinase, GSK3β: glycogen synthase kinase 3 beta; Bam32: B-cell adapter molecule of 32 kDa; Rac: Ras-related C3 botulinum toxin substrate 1; Ras: GTPase HRas; RasGRP3: Ras guanyl-releasing protein 3; CARMA1: caspase recruitment domain family, member 11; BCL-10: B cell lymphoma 10; MALT1: mucosa associated lymphoid tissue lymphoma translocation gene; IKKα: inhibitor of nuclear factor kappa-B kinase subunit alpha; IKKβ: inhibitor of nuclear factor kappa-B kinase subunit beta; IKKγ: inhibitor of nuclear factor kappa-B kinase subunit gamma; Raf: Raf proto-oncogene serine/threonine-protein kinase; MEK2: mitogen-activated protein kinase kinase 2; NFAT: nuclear factor of activated T-cells; ERK: extracellular signal-regulated kinase; IκB: NF-kappa-B inhibitor beta; NF-κB: nuclear factor NF-kappa-B; AP1: activator protein-1.