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. 2012 May 18;7(5):e35369. doi: 10.1371/journal.pone.0035369

Figure 10. T cell receptor signaling pathway representing the present and absent proteins in the pyrosequencing results.

Figure 10

Proteins appearing in turbot the transcriptome are represented in reddish color and absent proteins in grey color. PD-1: programmed cell death protein 1; CTLA4: cytotoxic T-lymphocyte-associated protein 4; CD45: cluster of differentiation antigen 45; CD8: cluster of differentiation antigen 8; CD4: cluster of differentiation antigen 4; CD3ε: cluster of differentiation antigen 3 epsilon chain; CD3γ: cluster of differentiation antigen 3 gamma chain; CD3δ: cluster of differentiation antigen 3 delta chain; Cd3ζ: cluster of differentiation antigen 3 zeta chain; TCRα: T cell receptor alpha chain; TCRβ: T cell receptor beta chain; CD40L: cluster of differentiation antigen 40 ligand; ICOS: inducible T-cell co-stimulator; CD28: cluster of differentiation antigen 28; SHP1: protein-tyrosine phosphatase-1; LCK: lymphocyte-specific protein tyrosine kinase; FYN: proto-oncogene tyrosine-protein kinase Fyn; LAT: linker for activation of T cells; GRB2: growth factor receptor-binding protein 2; SOS: son of sevenless; PI3K: phosphatidylinositol-4,5-bisphosphate 3-kinase; CBL: Casitas B-lineage lymphoma; ZAP70: zeta-chain (TCR) associated protein kinase; GADS: GRB2-related adaptor protein 2; PCL-γ1: phospholipase C gamma 1; PKCθ: protein kinase C theta; PDK1: pyruvate dehydrogenase kinase isoform 1; AKT: Rac serine/threonine-protein kinase; SLP-76: SH2 domain-containing leukocyte protein of 76 kDa; IKT: IL2-inducible T-cell kinase; RasGRP1: Ras guanyl-releasing protein 1; TAK1: TGF-beta activated kinase 1; CARMA1: caspase recruitment domain family, member 11; BCL-10: B cell lymphoma 10; MALT1: mucosa associated lymphoid tissue lymphoma translocation gene; COT: cancer Osaka thyroid oncogene; GSK-3β: glycogen synthase kinase 3 beta; NCK: NCK adaptor protein 1; VAV: vav guanine nucleotide exchange factor; Ras: GTPase HRas; MKK7: mitogen-activated protein kinase kinase 7; Dlgh1: disks large protein 1; NIK: NF-kappa-beta-inducing kinase; P38: p38 MAP kinase; PAK: p21-activated kinase 1; Rho/Cdc42: cell division control protein 42; Raf: Raf proto-oncogene serine/threonine-protein kinase; JNK2: c-Jun N-terminal kinase 2; IKKα: inhibitor of nuclear factor kappa-B kinase subunit alpha; IKKβ: inhibitor of nuclear factor kappa-B kinase subunit beta; IKKγ: inhibitor of nuclear factor kappa-B kinase subunit gamma; MEK2: mitogen-activated protein kinase kinase 2; IκB: NF-kappa-B inhibitor; NF-κB: nuclear factor NF-kappa-B; ERK: extracellular signal-regulated kinase; NFAT: nuclear factor of activated T-cells; AP1: activator protein-1.