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. 2012 May 18;7(5):e36590. doi: 10.1371/journal.pone.0036590

Figure 2. Cerebral MRI examination in the CADASIL family members.

Figure 2

ΙΙ:5, the proband, was a 60-year-old male affected family member. ΙΙΙ:31, ΙΙΙ:32, ΙΙΙ:33 and ΙΙΙ:34 were the children of the proband (ΙΙ:5). ΙΙ:5 and ΙΙΙ:32 showed evident clinical features, but ΙΙΙ:31, ΙΙΙ:33 and ΙΙΙ:34 did not show any clinical feature, although they were all mutation carriers (see the long T1 and T2 signals). ΙΙΙ:25, ΙΙΙ:15, ΙV:25, ΙV:10 and ΙV:11 were healthy core family members. ΙΙΙ:4 is a patient with l massive cerebral infarction, who did not have the R133C mutation.