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. 2012 May 18;7(5):e36590. doi: 10.1371/journal.pone.0036590

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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DNA sequence chromatogram of the R133C mutation in NOTCH3 and multiple-sequence alignment of NOTCH3 protein family. The C→T transition at position 475 resulting in the R133C mutation is located within a highly conserved region. A: DNA sequence chromatogram of the unaffected family members and ΙΙΙ:4; B: DNA sequence chromatogram of the affected family members and ΙΙΙ:31 and ΙΙΙ:33; C: multiple-sequence alignment of NOTCH3 protein family.