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. 2012 May 18;7(5):e37220. doi: 10.1371/journal.pone.0037220

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Arikata et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Cynomolgus macaques were subcutaneously immunized twice (in weeks 0 and 2) with a whole virus particle vaccine (#312, #775 and #784, orange symbols) or with a split vaccine (#729, #742 and #750, blue symbols) derived from Hokkaido2. Sera and swab samples were collected in indicated weeks after the first vaccination. IgM (A), IgG (B, E), IgA (C, F), and IgG1 (D) antibodies specific for Hokkaido2 antigens in sera (A-D) and nasal swab samples (E, F) were analyzed using ELISA. Optical densities at 450 nm are shown. In IgM and IgA measurements (A, C, F), the OD450 values before vaccination as non-specific background responses were subtracted from those after vaccination.