Figure 4. Body temperatures of macaques after inoculation of the pandemic (H1N1) 2009 influenza virus.

Cynomolgus macaques were subcutaneously immunized with the whole particle vaccine (middle column) or with the split vaccine (right column). Cynomolgus macaques injected with saline were used as unvaccinated controls (left column). On day 0, 7 weeks after the second vaccination, Narita1 (2×10⁵ TCID₅₀) was inoculated into nasal cavities of the macaques. Lines horizontally drawn indicate average temperature levels at pre-infection.