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. 2012 May 18;7(5):e37220. doi: 10.1371/journal.pone.0037220

Figure 6. Neutralization activities of serum samples after infection with Narita1.

Figure 6

Cynomolgus macaques were vaccinated with saline (A, D), whole particle vaccine (B, E), or split vaccine (C, F) as described in the legend to Fig. 1. Macaques were inoculated with Narita1 as described in the legend to Fig. 4. Sera were collected on indicated days after the challenge infection. Fifty percent neutralization titers against Hokkaido2 (A-C) and Narita1 (D-F) were determined. Statistically significant differences of average neutralization titers between the whole particle vaccine group and split vaccine group are indicated with asterisks (P<0.05 with Student’s t-test).