Table 4. Virulence gene profile and genetic characteristics of 53 MuH MRSA isolates from Shanghai and Wenzhzou, China.
Strain | Virulence gene profile | agrtype | PFGE-SCCmec-spa # [4] | MLSTtype* | |||||
Involved in toxin mediated disease and/or sepsisdisease and/or sepsis | Involved in attachment | Involved in evading/destroying hostdefenses | Involved in tissue invasion/penetration invasion/penetration invasion/penetration invasion/penetration | Involved in persistence | Others | ||||
Shanghai strain | |||||||||
1, 3, 4, 5, 6 | hla, hlb, seg, sei, tst, sec | fnbA, clfA, clfB, ebpS, bbp, cna | hlg, sbi, cap-8, map, pvl | ssp, sak | icaD, icaA | sarA | 3 | N-I-t318 | ST284 |
2 | hla, hlb, seg, sei, tst, sec | fnbA, clfA, clfB, ebpS, bbp, cna | hlg, sbi, cap-8, map, pvl | ssp, sak | icaD, icaA | sarA | 3 | N-IA-t318 | ST284 |
7 | hla, hlb, seg, sei, tst, sec, sej | fnbA, clfA, clfB, ebpS | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | L1-II-t002 | ST5 |
15 | hla, seg, sei, sej | fnbA, clfA, clfB, ebpS | hlg, sbi, map | ssp | icaD | sarA, efb | 2 | L2-III-t002 | ST5 |
8 | hla, hlb, sea | fnbA, clfA, clfB, ebpS, cna, fnbB | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | P2-III-t037 | ST239 |
9, 11 | hla, hlb, sea | fnbA, clfA, clfB, ebpS, cna, fnbB | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | P1-III-t037 | ST239 |
10 | hla | fnbA, clfB, fnbB | hlgv, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | O-III-t377 | ST630 |
12 | hlb | fnbA, clfB, ebpS, cna | hlgv, sbi | ssp, sak | icaD | 2 | I-III-t037 | ST239 | |
13 | hla | fnbA, ebpS, cna | hlgv, sbi | icaD | 2 | I-III-t037 | |||
14 | hla | fnbA, clfB, ebpS, cna | hlgv, sbi | icaD | 2 | I-III-t037 | |||
16 | hla, tst | clfB, ebpS, | hlgv, sbi, cap-8 | icaD | 2 | K-III-nt | ST239 | ||
17 | hla, hlb, seg, sei | fnbA, clfA, clfB, ebpS, fnbB | hlg, sbi, cap-8, map | ssp | icaD, icaA | sarA, efb | 1 | D1-IIIA-t037 | ST239 |
26 | hla, sea | fnbA, clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | D2-IIIA-t037 | ST239 |
18 | hla, hlb, seg, sei, tst, sec | fnbA, clfA, clfB, ebpS | hlg, sbi, cap-8, map | ssp | icaD, icaA | sarA, efb | 1 | M2-IIIA-t002 | ST5 |
23 | hla, hlb, seg, sei, tst, sec, sea | clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map, pvl | ssp, sak | icaD, icaA | sarA, efb | 1 | M1-IIIA-t002 | ST5 |
24 | hla, hlb, seg, sei, tst, sec, sea | fnbA, clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | M1-IIIA-t002 | |
19 | hla, hlb, sea | fnbA, clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 3 | E-IIIA-t127 | ST1 |
20 | hla, hlb, seg, sei, tst | clfA, clfB, bbp, ebpS, cna | hlg, sbi, cap-8 | ssp, sak | icaD, icaA | sarA, efb | 1 | F2-II-t002 | ST5 |
28 | hla, hlb | fnbA, clfA, clfB, ebpS | hlg, sbi, map | ssp, sak | icaD, icaA | sarA, efb | 1 | F1-II-t002 | ST5 |
21 | hla, hlb, seg, tst, sec | fnbA, clfA, clfB, ebpS, fnbB | hlg, sbi, cap-8, map, pvl | ssp, sak | icaD, icaA | sarA, efb | 1 | C-IIIB-t037 | ST239 |
22 | hla, hlb, seg, sei, tst, sec, sea sea, | fnbA, clfA, clfB, ebpS, cna, fnbB | hlg, sbi, map | ssp, sak | icaD, icaA | sarA, efb | 1 | A5-IIIA-t037 | ST239 |
27 | hla, hlb, sea | fnbA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD | sarA, efb | 1 | A5-IIIA-t037 | |
25 | hla, seg, sei | fnbA, clfB, ebpS, cna | hlgv, sbi, cap-8 | sak | icaD | sarA, efb | 1 | Q-IIIA-t985 | ST5 |
Wenzhou strain | |||||||||
29 | hla, hlb, seg | fnbA, clfB, ebpS, cna, fnbB | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | J-I-t189 | ST188 |
30 | hla | clfB, ebpS, cna | hlgv, sbi, cap-8 | ssp | icaD | 2 | A1-IIIA-t030 | ST239 | |
31, 32, 33 | hla, hlb, sea, seg, | fnbA, clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 11 | A1-IIIA-t030 | |
35, 40, 42, 43, 50, 51, 53 | hla, hlb, sea, | fnbA, clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | A1-IIIA-t030 | |
52 | hla | clfB, ebpS, cna | hlg, cap-8 | sak | icaD | sarA | 2 | A1-IIIA-t030 | |
34 | hla, hlb | fnbA, clfA, clfB, bbp | hlg, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | H-IIIA-t2505 | ST239 |
36, 37, 38, 39 | hla, hlb, sea, | fnbA, clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | A2-IIIA-t030 | ST239 |
41, 44, 46 | hla, hlb, sea, | fnbA, clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | B-IIIA-t030 | ST239 |
45 | hla | fnbA, clfB, ebpS, cna | hlg, sbi, cap-8 | ssp, sak | icaD | efb | 2 | B-IIIA-t030 | |
47 | hla, hlb, sea | clfB, cna | hlg, sbi, cap-8 | sak | icaD, icaA | sarA | 1 | A4-IIIA-t030 | ST239 |
48 | hla, hlb, sea | fnbA, clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | G-IIIA-t030 | ST239 |
49 | hla, hlb, sea | fnbA, clfA, clfB, ebpS, cna | hlg, sbi, cap-8, map | ssp, sak | icaD, icaA | sarA, efb | 1 | A3-IIIA-t030 | ST239 |
MLST (multilocus sequence typing) was performed on representative isolates for each PFGE-SCCmec-spa type;
nt: nontypable; agr: accessory gene regulator; PFGE: pulsed-field gel electrophoresis; SCCmec:
staphylococcal chromosomal cassette mec; spa: staphylococcal protein A.