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. 2012 May 18;7(5):e37017. doi: 10.1371/journal.pone.0037017

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Dussaubat et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

The composite functional association network derived from different genomic and proteomic data sources was generated with GeneMania using the Drosophila orthologs of bee genes. Physical and genetic interactions between genes are indicated by dot and solid lines, respectively. Grey and white circles represent implemented genes (known genes affected by Nosema) and new genes predicted to be functionally associated to the known genes, respectively. The size of the predicted gene circle provides an indication of its interaction score. Except ETS-domain lacking (edl), the predicted genes roundabout (robo), longitudinal (lola), Cyclin D (CycD), Optix, kekkon-1 (kek1) had bee orthologs: GB17658, GB12094, GB14028, GB16761 and GB17490.