Table 3. Pathways of differentially-regulated miRNAs.

Pathways	Genes (REF)	Targets of miRNAs
	#	#	expected	+/−	P value
Up-regulated miRNAs
TGF-beta signaling pathway	143	40	8.98	+	1.98E-14
Angiogenesis	193	41	12.12	+	4.67E-11
EGF receptor signaling pathway	138	34	8.66	+	4.88E-11
PDGF signaling pathway	162	37	10.17	+	5.71E-11
PI3 kinase pathway	110	29	6.91	+	2.76E-10
Integrin signalling pathway	185	38	11.62	+	5.87E-10
Interleukin signaling pathway	160	33	10.05	+	7.00E-09
FGF signaling pathway	125	28	7.85	+	1.75E-08
Insulin/IGF pathway-protein kinase B signaling cascade	83	22	5.21	+	3.41E-08
Ras Pathway	80	21	5.02	+	8.10E-08
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	36	14	2.26	+	1.23E-07
Wnt signaling pathway	348	50	21.85	+	1.36E-07
Down-regulated miRNAs
Integrin signalling pathway	185	87	26.74	+	1.50E-20
EGF receptor signaling pathway	138	72	19.95	+	1.33E-19
FGF signaling pathway	125	67	18.07	+	6.33E-19
Angiogenesis	193	83	27.90	+	1.86E-17
PDGF signaling pathway	162	68	23.42	+	4.25E-14
Wnt signaling pathway	348	111	50.30	+	6.70E-14
Ras Pathway	80	44	11.56	+	2.50E-13
TGF-beta signaling pathway	143	58	20.67	+	1.12E-11
PI3 kinase pathway	110	47	15.90	+	1.84E-10
p53 pathway	127	51	18.36	+	2.62E-10