Figure 5. Model Predictions.

A) Percentage of contact time between cell types in a mature crypt observed for 80 days. Colour code as in Figure 3. B) The chance of successful propagation of mutations affecting stem cells is ∼50% when the mutated cell is on the floor of the crypt and <2% for locations above. C) The time for the propagation of a mutation to the stem cell compartment is shorter when the mutation decreases the duration of the division cycle. Black columns show time for the propagation of mutated cells with 10-fold shorter division cycle, grey columns for 2-fold shorter, and white columns when division cycle is not affected. D) Time to replenish the crypt with the initial number of cells (•) and to recover the cellular structure of mature crypts after random killing of cells in the crypt (○). E) The numerical recovery rate of the injured crypt is 0.78 cells/day. The maturation rate is 0.34 cells/day. The time required to reach the original number of cells for an injured crypt that has lost half of its cells is approximately 0.9 days while the time required to reach a structural steady state is approximately 2 days. F) Time to replenish the bottom of the crypt with 10 Lgr5^hi cells after random killing of stem cells.