Figure 1.

Effect of α7nAChR deficiency in non–BM-derived cells and BM-derived cells on vagus nerve–mediated TNF suppression in endotoxemia. Mice with α7nAChR deficiency either in non–BM-derived (nBMα7⁰) (n = 6) (A) or BM-derived cells (BMα7⁰) (n = 5) (B) were subjected to vagus nerve stimulation followed by intraperitoneal endotoxin injection. Serum TNF was measured 90 min after endotoxin administration. Median TNF levels in pg/mL (lower quartile–upper quartile) were Sham, 476 (279–521), and vagus nerve stimulation (VNS), 159 (114–287), in nBMα7⁰ mice and Sham, 275 (265–400), and VNS, 508 (428–594), in BMα7⁰ mice. Results in diagrams are expressed as the median TNF as percent of sham (lower quartile–upper quartile). *P < 0.05.