Table 1.
Representative gene expression profile in HoxD10 transfectants compared with empty vector control (fold change) by cDNA microarray
| Gene symbol | Gene description | GenBank accession | Fold change | Gene function |
|---|---|---|---|---|
| ADAM28 | ADAM metallopeptidase domain 28 | NM_014265 | 3.84 | Ad,Pa |
| ALOX5 | arachidonate 5-lipoxygenase | NM_000698 | 2.10 | Ad,An,Ap,CC,M,P,ST |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | NM_006305 | 2.88 | Ap,P |
| AQP3 | aquaporin 3 (Gill blood group) | NM_004925 | 0.43 | I,M,P |
| CALB1 | calbindin 1, 28kDa | NM_004929 | 3.25 | Ap,CC,M,ST |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | NM_002996 | 3.50 | Ad,An,Ap,M,P |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | NM_002416 | 2.19 | Ad,An,Ap,CC,I,M,P,ST |
| FLG | filaggrin | NM_002016 | 0.41 | Ad,Ap,CC,I,M,P |
| GATA6 | GATA binding protein 6 | NM_005257 | 2.01 | Ad,Ap,P |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | NM_004131 | 0.48 | Ad,Ap,I,P |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | NM_005335 | 5.10 | Ap,M,P,ST |
| GFBP3 | insulin-like growth factor binding protein 3 | NM_001013398 | 2.33 | Ad,An,Ap,CC,I,M,P,ST |
| IL7R | interleukin 7 receptor | NM_002185 | 2.11 | Ad,Ap,CC,I,P,ST |
| IL8 | interleukin 8 | NM_000584 | 2.29 | Ad,An,Ap,CC,I,M,P,ST |
| KLK11 | kallikrein-related peptidase 11 | NM_144947 | 0.43 | Ap,M,P |
| KRT18 | keratin 18 | NM_000224 | 0.36 | Ad,An,Ap,CC,I,M,P,ST |
| KRT5 | keratin 5 | NM_000424 | 0.25 | Ad,Ap,I,P |
| KRT6A | keratin 6A | NM_005554 | 0.29 | I,P |
| MME | membrane metallo-endopeptidase | NM_007289 | 0.43 | Ad,An,Ap,CC,I,M,P,ST |
| NTS | neurotensin | NM_006183 | 0.25 | Ad,An,Ap,CC,I,M,P,ST |
| PDGFRL | platelet-derived growth factor receptor-like | NM_006207 | 2.82 | P,I |
| RAC2 | Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | NM_002872 | 0.16 | Ad,Ap,CC,I,M,P,ST |
| SAA1 | serum amyloid A1 | NM_000331 | 2.07 | Ad,An,Ap,I,M |
| TNF | tumor necrosis factor (TNF superfamily, member 2) | NM_000594 | 2.07 | Ad,An,Ap,CC,I,M,P,ST |
| TUSC3 | tumor suppressor candidate 3 | NM_178234 | 0.41 | Ap,CC,I |
| UPK1B | uroplakin 1B | NM_006952 | 0.40 | ST |
a
Ad, adhesion; P, proliferation; An, angiogenesis; Ap, apoptosis; CC, cell cycle; M, migration; ST, signal transduction; I, invasion.