Figure 3.

Attenuation of cell migration and expansion by anti-miR-184 and pre-miR-204. (A) Cell migration and expansion of LE cells within capsular bag cultures monitored by phase-contrast microscopy after 0–2 d treatment with anti-miR-184 compared with anti-miR control and pre-miR-204 compared with pre-miR control. (B) Graphs demonstrate percent cell confluence determined from d 1 and d 2 in (A) by measuring the average area of cells that migrated to the denuded area of the capsular bag. The data were derived by dividing each capsular bag into four quadrants followed by measuring the average area of cells that migrated to the denuded area. Data were analyzed by two-way ANOVA by entering the standard deviation from two donor eyes with four measurements each (representing four quadrants). Error bars represent standard deviations. P < 0.05 was used as a criterion for significance.