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. 2012 Jan 18;18(1):528–538. doi: 10.2119/molmed.2011.00463

Figure 8.

Figure 8

Summary diagram of miR-184 and miR-204 competitive RNA network in control of mouse secondary cataract. The SC-determined broad-spectrum miRNA expression profile revealed changes in expression patterns of major lens differentiation/regeneration-and EMT-associated miRNAs (upregulation indicated with red arrows and downregulation indicated with green arrows). Accordingly, the microRNAs miR-184 and miR-204 were chosen for further analysis because of their differential expression patterns during SC that can also be observed during lens differentiation, regeneration and cataract etiology (25,27,34,35). The experimental manipulation of miRNA expression by the anti-miR-184–dependent downregulation of miR-184 and pre-miR-204–dependent upregulation of miR-204 is suggested to result in the mechanistic interplay with other co-or counterregulatory miRNAs for the modulation of potential SC target mRNAs and attenuation of SC EMT. Vice versa, the miRNA-dependent modulation of SC target mRNAs might include alterations in transcription factors relevant for expression of SC EMT attenuating miRNAs.