Figure 3. Boundaries are shared across cell types and conserved in evolution.
a, Overlap of boundaries between cell types. b, Genome browser shot of a cortex enriched dynamic interacting region that overlaps with the Foxg1 gene. c, Foxg1 expression in mouse ES cells and cortex as measured by RNA-seq. d, Heat map of the gene expression ratio between mouse ES cell and cortex of genes at dynamic interactions. e, Pie chart of inter- and intra-domain dynamic interactions. f, Overlap of boundaries between syntenic mouse and human sequences (p-value < 2.2*10−16 compared to random, Fisher’s exact test). g and h, Genome browser shots showing domain structure over a syntenic region in the mouse (g) and human ES cells (h). Note: the region in humans has been inverted from its normal UCSC coordinates for proper display purposes.