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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Biomaterials. 2012 Apr 22;33(21):5325–5332. doi: 10.1016/j.biomaterials.2012.04.004

Fig. 2.

Fig. 2

Optimal regularization parameter chosen from L-curve analysis. (A) L-curve from experimental reconstructions is used to balance the size of residual (2-norm of Ax′ – b) and size of regularized solution (2-norm of x′). A is the whole Jacobian matrix computed based on a MC forward model; x′ is reconstructed fluorescence distribution; b is obtained from the fluorescence measurement. (B) Curvature of L-curve [22] with respect to regularization parameters is used to choose the best regularization parameter.