Figure 3.

The Core Molecular Clock Is Not Altered in Bdr Mice

(A) Representative actograms of mouse running-wheel activity counts (black bars displayed in 10 min bins) show comparable free-running rhythmicity and activity patterns in Bdr compared to controls under both DD and 150 LL cycles. Increased activity fragmentation compared to wild-types is observed in the Bdr mice; this is reflected in periodogram amplitude values for both DD and LL (Figure 1).

(B) The free-running period or tau (τ) in both DD and LL shows no significant difference (ANOVA, planned comparison) between Bdr and wild-type mice as a marker of core clock stability, data summarized in Table S2. Data are presented as mean ± SEM.

(C) Representative bioluminescence of organotypic SCN slice culture from the Per2:Luc reporter line either wild-type (blue) or Bdr mutant (red).