Fig. P1.

Efficacy of single-agent treatment of the IGF1R small molecule inhibitor NVP-AEW541 in orthotopic, but not s.c., Wilms tumor models in vivo. WiT49 cells implanted in the flank of mice form a poorly differentiated mass of cells with little resemblance to human Wilms tumor histology (A), and which do not respond to targeted inhibition of IGF1R (B). By contrast, cells grown in the kidney invade deep into the renal parenchyma and show morphological features suggestive of anaplastic Wilms tumor (C). These tumors show a significant reduction in tumor volume and tumor weight (D) after treatment with NVP-AEW541 as a single agent.