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. 2012 Apr 30;109(20):7765–7769. doi: 10.1073/pnas.1205132109

Fig. 3.

Fig. 3.

STAT3 acetylation affects its interaction with DNMT1. (A) Western blotting following immunoprecipitation with STAT3 antibodies detecting interaction of acetylated STAT3 with DNMT1 in growing A2058 tumors expressing either STAT3 wild-type or acetylation mutant (KR). (B) Effects of resveratrol on acetylated STAT3 as well as its interaction with DNMT1 in A2058 tumors analyzed by Western blotting. (C) DNA methylation analysis of the PTPN6, CDKN2A, and SOCS3 promoters upon abrogating STAT3 acetylation in tumors (the mean and range for two experiments with pooled tumors is shown). (D) A2058 tumor growth measured at the indicated time points. Postintratumoral injection of either solvent control or 50 μM of resveratrol. n = 8; ***P < 0.0001.