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. 2012 Apr 30;109(20):7765–7769. doi: 10.1073/pnas.1205132109

Fig. 4.

Fig. 4.

Resveratrol reduces STAT3 acetylation, restores ERα expression and sensitizes TNBC cells to antiestrogen therapy. (A) RNA expression levels of ERα (n = 3) (Left) or protein expression levels of ERα and acetylated STAT3 (9) in MDA-MB468 cells treated with either solvent control or resveratrol. (B) Quantification of ERα promoter DNA methylation levels in control and resveratrol-treated MDA-MB468 cells; means ± SD. (C) Cell proliferation assay to measure effects of treatments with tamoxifen or resveratrol alone or in combination on the viability of MDA-MB468 cells (n = 8); *P = 0.0146. (D) Growth curve of MDA-MB468 tumors receiving the indicated treatment twice a week (n = 6); ***P < 0.0001.