Fig. 1.

Characteristics of mice fed HFD. Mice fed a 45% mixed fat diet (white bars) consumed similar amounts of food in grams as mice fed a 10% fat diet (black bars) but ingested significantly more calories (A). Data shown are average food consumption per day for the entire 180-d experiment. (B) Mice fed a 45% fat diet (○) gained significantly more weight than mice fed a 10% fat diet (●). (C) Serum leptin in mice fed a 45% fat diet (white bars) was significantly elevated compared with mice fed a 10% fat diet (black bars; n = 7–8 mice per group). **P < 0.01.