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. 2012 Apr 30;109(20):7776–7781. doi: 10.1073/pnas.1111135109

Fig. 2.

Fig. 2.

Altered glycogene expression induced by EGF or bFGF. (A) Expression of the sialyltransferase and fucosyltransferase genes involved in the sLex/a synthesis was screened by conventional RT-PCR. (B and C) Expression levels of ST3GAL1/3/4, FUT3/6 (B), and FUT2 (C) were determined by quantitative RT-PCR. The mean 2-ΔΔCT values ± SD from three independent experiments are shown. Statistic analysis was performed by t test. Asterisks, P < 0.005 (B) and P < 0.00005 (C) compared with the untreated cells; NS, not significant (P > 0.05). (D) Scheme of the sLex, Ley, sLea, and Leb synthetic pathways showing the roles of ST3GAL1/3/4, FUT3, and FUT2. Note that FUT2 competes with ST3GAL3/4 for sLex synthesis and with ST3GAL1 for sLea synthesis, respectively.