Figure 7.
Basal response properties of individual neurons in the visual cortex of Bdnfklox/klox mice. A, Spontaneous firing rates in broad-spiking (putative excitatory) cells (WT: +/+, 295 cells; Bdnfklox/klox: k/k, 274 cells). B, Response rates to the optimal grating (best orientation at best spatial frequency) recorded in the same populations as those in A. C, Orientation selectivity index (OSI) of broad-spiking cells that were responsive to the gratings stimuli (>2 spikes/s). +/+, 240 cells; k/k, 237 cells. D, Orientation tuning width in broad-spiking units that were responsive to the gratings (same populations as in C). E, Preferred spatial frequency in broad-spiking cells responsive to the gratings (same population as in C). F, RF size in broad-spiking cells. RF size was analyzed in selected cells from the population shown in A and B based on responses of >4 spikes/s to the bar with optimal orientation. +/+, 261 cells; k/k, 234 cells. G, Spontaneous firing rates in narrow-spiking (putative inhibitory) cells. +/+, 119 cells; k/k, 88 cells. H, Response rates to the optimal grating of narrow-spiking cells (same populations as in G). All data are presented as the cumulative frequency distribution. P values derived from Kolmogorov–Smirnov tests are indicated in A–H.