Figure 8.

Bdnf^klox/klox mice show impaired recovery of responsiveness after ending MD during the critical period. A, Experimental schedule. B, C, Change in visual cortical responses to the closed eye (B) and to the open eye (C) measured by repeated optical imaging of intrinsic signals, after 5 d of MD followed by 4 d of BV (recovery) in Bdnf^klox/klox mice (k/k, n = 6) and WT littermates (+/+, n = 6). D, ODI calculated from data shown in B and C. E, F, Change in visual cortical responses to the closed eye (E) and to the open eye (F) measured by repeated optical imaging of intrinsic signals, after 5 d of MD followed by 4 d of BV (recovery) in Bdnf^+/− mice (+/−, n = 4) and their +/+ littermates (n = 4). G, ODI derived from data shown in E and F. H, Percentage change from baseline in closed-eye responses, calculated from data presented in B and E. Two populations of +/+ mice were pooled as there were no significant differences between them. I, Percentage change from baseline in open-eye responses, calculated from data shown in C and F. WT mice in C and F were combined. Data represent mean ± SEM. Response amplitude is expressed as fractional change in reflectance (ΔR/R) × 10⁴. ‡, p < 0.01, †, p < 0.05 compared with baseline, repeated measure ANOVA followed by multiple comparisons with Bonferroni's correction. *p < 0.05 between genotypes, one-way ANOVA followed by multiple comparisons with Bonferroni's correction.