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. Author manuscript; available in PMC: 2012 Nov 17.
Published in final edited form as: Nature. 2012 May 9;485(7398):333–338. doi: 10.1038/nature11040

Figure 3. Mice lacking cardiac PGC-1α have reduced microvascular density that is worsened by pregnancy.

Figure 3

a–b, Relative mRNA expression of the indicated genes (a) and VEGF protein levels (b) in HKO versus control hearts. c–d, Vascular density in hearts from CT and HKO mice nulliparous or post-partum (PP). Representative images stained for CD31 (PECAM) are shown in c, and quantified in d. e–f, Reduced cardiac MIBI uptake in PP HKO versus PP CT animals. Representative SPECT/CT images are shown in f, and quantified in e. n≥5 for all groups. Error bars are +/− SE. *p<0.05 versus control.