Table 2.
APOE Genotype Frequency by Population and Alzheimer Disease Status
| Population | Genotype, No. (%) of Subjectsa |
||||||
|---|---|---|---|---|---|---|---|
| ε2/ε2 | ε2/ε3 | ε2/ε4 | ε3/ε3 | ε3/ε4 | ε4/ε4 | Missing | |
| African American | |||||||
| Cases | 0 | 25 (4.9) | 19 (3.7) | 147 (28.7) | 227 (44.2) | 78 (15.2) | 17 (3.3) |
| Controlsb | 2 (0.4) | 67 (13.3) | 12 (2.4) | 210 (41.7) | 172 (34.1) | 18 (3.6) | 15 (3.0) |
| White | |||||||
| Cases | 9 (0.3) | 112 (3.1) | 93 (2.6) | 1045 (29.3) | 1743 (48.9) | 552 (15.5) | 14 (0.4) |
| Controls | 21 (0.3) | 673 (10.8) | 136 (2.2) | 3562 (57.4) | 1489 (24.0) | 182 (2.9) | 139 (2.2) |
Abbreviation: APOE, apolipoprotein E.
a
Percentages have been rounded and might not total 100.
b
The total number of controls sums to 6202 rather than 6205 owing to the presence of 3 rare APOE isoforms observed in the Framingham Heart Study subjects.