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. Author manuscript; available in PMC: 2012 May 21.
Published in final edited form as: Arch Neurol. 2011 Dec;68(12):1569–1579. doi: 10.1001/archneurol.2011.646

Table 4.

Most Significantly Associated Markers in the APOE Region in African American and White Cohorts

Marker Position, dbSNP Build 129. bp Gene Effect Allele Unadjusted for APOE
 APOE Genotype Adjusted
OR P Value Directiona OR P Value Directiona
African American
 rs6859 50 073 874 PVRL2 A 1.58 5.39 × 10−7 + + 1.30 .0087 + +
 rs3852861 50 074 901 PVRL2 T 0.64 5.99 × 10−5 − − 0.78 .038 − −
 rs157582 50 088 059 TOMM40 T 1.60 3.26 × 10−6 + + 1.15 .222 − +
 rs157583 50 088 513 TOMM40 T 2.08 2.48 × 10−5 + + 0.92 .700 − −
 rs8106922 50 093 506 TOMM40 A 1.48 9.73 × 10−5 + + 1.18 .144 − +
 rs1160985 50 095 252 TOMM40 T 0.65 4.92 × 10−5 − − 1.04 .730 + −
 rs10119 50 098 513 TOMM40 A 1.80 5.95 × 10−7 + + 1.07 .614 − +
 rs445925 50 107 480 5′ APOC1 A 1.57 3.02 × 10−4 + + 1.13 .443 + +
White
 rs6857 50 084 094 PVRL2 T 3.23 1.49 × 10−108 + + ?? + 1.50 4.98 × 10−7 + + ?? +
 rs157580 50 087 106 TOMM40 A 1.70 2.77 × 10−29 + + ?? + 1.09 .130 + + ?? +
 rs2075650 50 087 459 TOMM40 A 0.35 1.70 × 10−94 − − ?? − 0.71 1.25 × 10−6 − − ?? −
 rs157582 50 088 059 TOMM40 T 2.73 2.54 × 10−91 + + ?? + 1.30 .0011 + − ?? +
 rs8106922 50 093 506 TOMM40 A 1.66 2.06 × 10−28 + + ?? + 1.02 .679 + − ? −
 rs1160985 50 095 252 TOMM40 T 0.58 2.78 × 10−33 − − ?? − 0.95 .326 − + ?? +
 rs10119 50 098 513 TOMM40 A 2.48 8.15 × 10−70 + + ?? + 1.22 .0051 + − ?? +
 rs4420638 50 114 786 APOC1 A 0.23 1.07 × 10−144 − − ? − − 0.61 1.54 × 10−7 − − ? − −

Abbreviations: APOC1, apolipoprotein C-I; APOE, apolipoprotein E; bp, base pairs; dbSNP, database single-nucleotide polymorphism; OR, odds ratio; PVRL2, poliovirus receptor-related 2; TOMM40, translocase of outer mitochondrial membrane 40 yeast homologue.

a

For the African American cohort, symbols indicate increased (+) or decreased (−) risk in the Genetic and Environmental Risk Factors for Alzheimer Disease Among African Americans and Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) data sets; for the white cohort, increased (+) or decreased (−) risk in the MIRAGE, Alzheimer Disease Neuroimaging Initiative, Framingham Heart Study, Canadian Study on Genetics of Alzheimer Disease Associations, and National Institute on Aging–Late-Onset Alzheimer’s Disease Family Study data sets.