Table 6.
Top-Ranked Genetic Association Findings From Genome-wide Survey in African Americans
| CHR | Position, dbSNP Build 129, bp | Gene | SNP | P Value | Effect Allele | AF | OR (95% CI) |
|---|---|---|---|---|---|---|---|
| 1 | 212 184 713a | – | rs340849a | 7.52 × 10−6 | A | 0.20 | 0.59 (0.47–0.75) |
| 2 | 17 291 066 | – | rs11889338 | 8.94 × 10−6 | A | 0.26 | 1.55 (1.28–1.88) |
| 2 | 27 760 977 | SLC4A1AP | rs17006206 | 2.30 × 10−6 | G | 0.10 | 2.05 (1.52–2.76) |
| 3 | 28 903 864 | – | rs2221154 | 2.58 × 10−6 | T | 0.19 | 0.57 (0.45–0.72) |
| 4 | 2 072 894 | POLN | rs1923775 | 5.61 × 10−6 | T | 0.25 | 1.60 (1.30–1.95) |
| 7 | 146 528 336 | CNTNAP2 | rs10273775 | 8.94 × 10−6 | G | 0.42 | 1.52 (1.27–1.84) |
| 8 | 122 978 868 | – | rs956225 | 8.71 × 10−6 | G | 0.03 | 0.30 (0.18–0.51) |
| 11 | 73 710 714 | – | rs3888908 | 9.52 × 10−6 | A | 0.15 | 1.72 (1.36–2.20) |
| 12 | 113 864 776 | – | rs10850408 | 9.25 × 10−7 | T | 0.34 | 0.63 (0.52–0.76) |
| 13 | 25 622 328 | – | rs17511627 | 5.01 × 10−6 | C | 0.17 | 1.75 (1.37–2.22) |
| 13 | 97 929 295 | STK24 | rs912330 | 3.79 × 10−6 | T | 0.14 | 0.54 (0.41–0.70) |
| Other SNPs of Interest From APOE ε4 Adjusted Analysis | |||||||
| 8 | 144 692 178 | ZC3H3 | rs3750208 | 7.28 × 10−6 | A | 0.04 | 0.37 (0.24–.057) |
| 12 | 29 812 934 | TMTC1 | rs302318 | 1.97 × 10−6 | C | 0.26 | 0.59 (0.48–0.74) |
| 13 | 43 064 019 | ENOX1 | rs17460623 | 9.37 × 10−6 | C | 0.10 | 0.49 (0.36–0.67) |
Abbreviations: AF, effect allele frequency; bp, base pairs; CHR, chromosome; CNTNAP2, contactin-associated protein-like 2; dbSNP, database single-nucleotide polymorphism; ENOX1, ecto-NOX disulfidethiol exchanger 1; OR, odds ratio; POLN, polymerase (DNA directed) nu; SLC4A1AP, solute carrier family 4 (anion exchanger), member 1, adaptor protein; SNP, single-nucleotide polymorphism; STK24, serine/threonine kinase 24; TMTC1, transmembrane and tetratricopeptide repeat containing 1; ZC3H3, zinc finger CCCH-type containing 3; –, indicates that the SNP is more than 50 kilobases from the nearest characterized gene.
Does not include multiple SNPs on CHR 1 that were redundant owing to strong linkage disequilibrium (pairwise R2 > 0.8) and CHR 3 (R2 > 0.7) and 1 SNP that did not meet minor allele frequency criteria in subjects from the Genetic and Environmental Risk Factors for Alzheimer Disease Among African Americans Study.