Figure 5.

Lack of effect of Fe₃O₄ NPs on delayed rectifier K⁺ current (I_K(DR)) in GH₃ cells. Cells, immersed in Ca²⁺-free Tyrode’s solution containing 1 μM tetrodotoxin and 0.5 mM CdCl₂, were held at −50 mV and depolarizing pulses ranging from −50 to +60 mV in 10 mV increments with a duration of 1 second were applied. Superimposed current traces shown in (A) are control, and those in (B) were recorded 2 minutes after the addition of 100 μg/mL Fe₃O₄ NPs. No discernible change in I_K(DR) kinetics and amplitude was demonstrated when cells were exposed to Fe₃O₄ NPs.

Note: The uppermost part indicates the voltage protocol used.

Abbreviation: Fe₃O₄ NPs, magnetite nanoparticles.