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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Mar 8;32(5):1246–1254. doi: 10.1161/ATVBAHA.111.241257

Figure 6. Hypothetical diagram depicting the proximal steps of Ox-PAPC signaling of IL-8 induction in vascular endothelial cells.

Figure 6

Ox-PAPC activates ADAMs on the vascular endothelial cell surface, and the activated ADAM processes HBEGF for EGFR activation, leading to IL-8 expression in the nucleus.