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. Author manuscript; available in PMC: 2012 May 21.
Published in final edited form as: Clin Endocrinol (Oxf). 2011 May;74(5):618–623. doi: 10.1111/j.1365-2265.2010.03968.x

Table 4.

logEstradiol (E2) rates of change as slopes according to obesity classification (BMI<30 vs BMI>30) and type 1 17β hydroxysteroid dehydrogenase (17β HSD) rs2830 genotypes

Type 1 17β HSD rs2830
Number of women Slopes (β, pg/ml) Slope as a proportion of the fastest rate of decline (%) Slope as a proportion of the rate of decline within obesity group (%)
BMI < 30 kg/m2
 AA 132 −0.0568* 56 56
 AG 220 −0.1013† 100 (referent) 100 (referent)
 GG 99 −0.0551* 54 54
BMI ≥ 30 kg/m2
 AA 87 −0.0062 6 12
 AG 93 −0.0507† 50 100 (referent)
 GG 40 −0.0046 5 9
*

Within genotype, BMI<30 group declines faster than BMI>30, P < 0.01.

†

Genotype slope is significantly different than other genotype slopes within the obesity group.