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SV-LEC proliferation and cytokines. (A) TNF-α, IFN-γ inhibited, IL-1β stimulated LEC proliferation (72 h). TNF-α, (5–20 ng/ml), IFN-γ (100–1000 U/ml) decreased LEC proliferation. IL-1β increased LEC proliferation: IL-1β, (5- 20 ng/ml). (B) HMEC-1a proliferation and cytokines: IFN-γ (100–1000 U/ml) dose dependently decreased HMEC-1a proliferation. IL-1β did not affect HMEC-1a proliferation. At 72 h, 5 ng/ml TNF-α increased HMEC-1a proliferation; (10 and 20 ng/ml:not significant).
