FIG. 5.
(a) In vitro AC device. (b) For direct AC stimulation, electrodes are placed inside the device chamber with the cells or tissue. The choice of electrode material depends on characteristics such as charge transfer, corrosiveness, biocompatibility, and cost.46,131 Before the experiment, electric measurements are taken inside the culture dish to verify that the desired current strength reaches the cells. Electric measurements may also be taken across each chamber for verifying desired voltages. Large resistances at each node may decrease voltage potential and overall charge delivered to the cells. (c) Group of six AC chambers. Color images available online at www.liebertonline.com/teb