Figure 5. The metabolic feature is an emergent property of RA-induced differentiation in SH-SY5Y cells.
(A) Oxygen consumption rate (OCR, black bars) and extracellular acidification rate (ECAR, gray bars) in D and U cells in response to increasing pyruvate concentrations in the absence of glucose. The pyruvate concentrations (in mM) are as indicated. (B) OCR (black bars) and ECAR (gray bars) in D and U cells in response to increasing glucose concentrations in the absence of pyruvate. The glucose concentrations (in mM) are as indicated. Saturating levels of both pyruvate and glucose did not increase OCR and ECAR in U-SH-SY5Y cells to that observed in D-SH-SY5Y cells. Data shown are the mean ± SEM, n = 6.