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. 2012 May 21;3:90. doi: 10.3389/fphar.2012.00090

Figure 3.

Figure 3

Kynurenine:tryptophan (Kyn:Tryp) ratio in unstimulated whole blood supernatants from healthy controls and IBS patients and following stimulation with: (A) TLR4 agonist LPS, (B) TLR5 agonist flagellin, and (C) TLR6/1 agonist FSL1. Data are expressed as mean ± SEM. Statistical differences between treatments and disease states were determined using two-way ANOVA with Bonferroni post hoc test. ***p < 0.001, Healthy control stimulated vs. unstimulated; $ p < 0.05, IBS stimulated vs. unstimulated; $$$ p < 0.001, IBS stimulated vs. unstimulated. There was no significant interaction between disease state and treatment following stimulation with the TL6/2 agonist FSL1 (F1,124 = 1.026, p = 0.313) not was there any alteration in the kynurenine:tryptophan ratio in either healthy controls or IBS subjects (Figure 3C).