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. Author manuscript; available in PMC: 2012 May 21.
Published in final edited form as: Neuroscientist. 2011 Jun 10;17(4):389–406. doi: 10.1177/1073858411404531

Figure 8. Triad of striatal DA, glutamate and GABA synapses on a medium spiny neuron dendrite bound together functionally by diffusible H2O2.

Figure 8

Generation of modulatory H2O2 when GABA as well as glutamate is released (center); GABAA-receptor (GABAAR) blockade by picrotoxin (+PTX, right), and with AMPA-receptor (AMPAR) blockade by GYKI-52466 (+GYKI, left) (circuitry and locations of receptors and mitochondria are from Smith and Bolam, 1990; Bernard and Bolam, 1998; Chen and others 1998; Fujiyama and others 2000) (modified from Avshalumov and others 2008; copyright American Physiological Society, used with permission).