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. 2012 Apr 3;205(12):1778–1787. doi: 10.1093/infdis/jis101

Figure 1.

Figure 1.

Mitochondrial DNA (mtDNA) to nuclear DNA (nDNA) ratio in muscle, adipose tissue, and peripheral blood mononuclear cells (PBMCs) by patient group. A, mtDNA/nDNA in adipose tissue is significantly higher in patients infected with human immunodeficiency virus (HIV) not on therapy and significantly lower in patients receiving antiretroviral therapy (ART) compared with HIV-negative controls, whereas muscle and PBMC mtDNA/nDNA were not different among the groups. PBMC and tissue samples available for analysis for all HIV-negative participants (n = 15). PBMCs were available for all HIV-positive participants (n = 46). Muscle samples were available for 45 HIV-positive participants (28 on ART, 17 no ART). Adipose tissue samples were available for 40 HIV-positive participants (25 on ART, 15 no ART). B, mtDNA/nDNA in adipose tissue is decreased in patients with clinical lipodystrophy. C, mtDNA/nDNA is decreased in the adipose tissue of HIV-infected patients receiving thymidine analogues (zidovudine or stavudine) and/or D-drugs (didanosine or stavudine). Individuals receiving stavudine were included in both the thymidine analogue and D-drug groups. Box plots indicate median, interquartile range (box) and the 5%–95% range (whiskers). Outliers indicated by solid circles. Comparisons between groups are nonsignificant except where indicated.