Figure 5.

Heat map of gene expression profile by a custom microarray. The findings for all 3 tissue types—fat, muscle, and peripheral blood mononuclear cells (PBMCs)—are shown. Each column represents an individual patient sample, and each row represents an individual gene. Differences in relative levels of gene expression (z score) are represented in color, where red indicates upregulation and green indicates downregulation relative to that of corresponding median gene expression in HIV-negative controls. The hierarchical analyses classified the genes into 9 distinct clusters based on differential expression pattern between the groups, indicated on the left. The numbers in parenthesis indicate the number of genes in each cluster. Functional annotation analysis identified biologically relevant pathways by cluster, indicated on the right for selected clusters.