Table 3.

Prognostic parameters in patients treated with high-dose chemotherapy for relapsed breast cancer ± local therapy to metastatic sites showing irradiation of metastatic lesions to be the only relevant therapy-related parameter (relapse-free interval, type of adjuvant treatment, pharmacokinetics of high-dose chemotherapy not significant [20])

	Relapse-free survival, %	pa
Her-2 status		0.003
Negative	71
Positive	27
Initial nodal status		0.01
1–3	74
> 3	36
Radiotherapy of metastatic lesions		0.01
Yes	63
No	18
Hormone receptor status		0.02
Positive	62
Negative	33
Category of primary tumor		0.02
pT1	73
pT2	52
pT3	64
pT4	0
Number of metastatic lesions		0.03
1	63
>1	29
Site of metastatic lesions		0.11
Local	67
Distant	59
Both	27
Surgery of metastatic lesions		0.73
Yes	56
No	52

^aUnivariate analysis.